Collavant n2

Native (undenatured) type II collagen

Make your move in the mobility market with Collavant n2 – a next generation collagen for joint health

About Collavant n2

What is Collavant n2?

Collavant n2 – the new name for b-2Cool – is a trusted source of quality native (undenatured) type II collagen extracted from chicken sternum. Endorsed by multiple scientific studies, it is highly efficacious at a low dose and supported by Bioiberica’s 20+ years’ experience in joint health and mobility innovation.

Collagen for joint health

Collagen is the core structural protein present in cartilage, providing tensile strength and toughness to the tissue. However, some common joint conditions can activate an autoimmune response against the body’s own endogenous type II collagen, impacting joint health

Oral administration of Collavant n2 helps to maintain joint health through a mechanism of action called Oral Tolerance, all at a low dose of 40 mg/day. This immune-mediated mechanism helps to regulate the body’s response to endogenous type II collagen, reducing its degradation^1,21. Scarpellini, M. et al. J. Orthop. Traumatol. 9, 81–87 (2008).
2. Mannelli, L. D. C.et al. Osteoporos. Int. 26, S191-S192 (2015). and supporting healthy joints.^1,3 1. Scarpellini, M. et al. J. Orthop. Traumatol. 9, 81–87 (2008).
3. Bakilan, F. et al. Eurasian J. Med. 48, 95–101 (2016).

https://vimeo.com/566173337/cde1b2323d

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Collagens are the most abundant family of proteins in the extra cellular matrix of connective tissues. They perform a variety of important biological functions, the most known of which is its structural role. According to the three-dimensional shape, 28 different types of collagen have been described. Type II collagen is the main structural protein in the cartilage and provides tensile strength and toughness to the tissue.

Some joint disorders involving inflammation and cartilage erosion are caused by an immune response against endogenous type II collagen. Collavant n2 is a product of natural origin supplying native type II collagen. The strictly controlled extraction and manufacturing process of Collavant n2 ensure is type II collagen to maintain its native form – the biologically active structure of the collagen molecule.

Native type II collagen works through an immune mediated mechanism of action called oral tolerance. It consists of a diminished immune response to a previously administered substance. When taken orally native type II collagen passes through the stomach without being denatured and reaches the Peyer’s patches in the small intestine. Peyer’s patches are lymphoid nodules responsible for immune surveillance of the intestine lumen. They activate or deactivate the immune response against foreign substances.

In the Peyer’s patch, native type II collagen is recognised by the immune cells. It's important to highlight that native type II collagen is not absorbed. It turns off the immune response against endogenous type II collagen by just interacting with the immune cells. Afterwards, immune suppressor cells reach the joint where they reduce collagen degradation.

Thanks to this specific mechanism of action, Collavant n2 dosage is very low: only 40 mg/day. Collavant n2 the trusted source of native type II collagen from Bioiberica.

Product information sheet

Ready to step into the future with Collavant n2? Discover how it can support your next innovation in the mobility market with our product information sheet.

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White paper

Do you want to stay one step ahead in the competitive andin the evolving collagen arena? Download our whitepaper to uncover the scientific evidence demonstrating native (undenatured) type II collagen’s efficacy in supporting joint health at a low dose and how this can help manufacturers meet demand for convenient products that offer real health benefits.

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These statements have not been evaluated by competent food authorities. The product is not intended to diagnose, treat, cure, or prevent any disease. This information is only for business-to-business use and not meant to be addressed to final consumers. Therefore, BIOIBERICA assumes no liability for the statements that the producer of the final product may include in its own publicity to consumers.