When the liver is affected, reduces the natural production of SAMe (S-adenosylmethionine), and also decreases levels of glutathione. This molecule is the most important liver detoxifying because it is a powerful natural antioxidant, helping the detoxification of various components to make them more soluble and excreted.

The addition of silybin and Phosphatidylcholine helps strengthen the beneficial effects of the use of SAMe, and is especially useful in these cases:

• Compromised liver function due to intoxication.

• Acute phases of liver insufficiency.

• Liver diseases with high inflammation.

DENAMARIN is a nutritional supplement designed to provide specific nourishment to help liver function in cases of acute liver insufficiency in dogs and cats.

Each tablet of DENAMARIN contains:

SAMe 225 mg

Silybin A+B (Phosphatidylcholine complex) 24 mg

CHEWABLE TABLETS

Available in boxes of 30 and 75 chewable tablets.

SAMe (S-Adenosylmethionine) participates in the formation of glutathione, which helps reduce the toxicity of different components by making them soluble and easier to excrete. Because it is a powerful natural antioxidant, glutathione is the most important liver detoxifier. In cases of liver disorder, the natural production of SAMe is reduced, which means glutathione levels are also lower. SAMe also helps stabilize the liver cell membrane and facilitates the process of bile-acid detoxification.

Silybin A+B is the most active form of silymarin. It neutralizes free radicals, thereby protecting liver cells from oxidative damage. It inhibits the adhesion of toxins and the production of leukotrienes, which are involved in inflammatory response.

Together with silybin, phosphatidylcholine increases the bioavailability and the speed at which silybin is metabolized in the hepatocytes.

The tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. To ensure the tablet is swallowed, cat owners should administer a small amount of water after administration of a tablet of DENAMARIN.

Administer DENAMARIN by mouth, following these dosage guidelines:

  Animal weight               Tablets per day

     < 3 kg                                     ¼

    3- 7 kg                                     ½

   7-14 kg                                     1

  14-20 kg                                    1½

  20-27 kg                                    2

  27-34 kg                                    2½

  34-41 kg                                    3

  41-48 kg                                    3½

    > 48 kg                                     4

Based on the veterinarian's criteria, the administration period may vary from 30 days to more extended periods, depending on the patient's pathology and improved response after administration of DENAMARIN. Response should be monitored to check the patient's improvement.

DENAMARIN has been shown to be well tolerated in dogs and cats, with a broad margin of safety.

Consult your veterinarian before using DENAMARIN or extending its period of use.